Appropriate treatment strategy for ground glass opacity—dominant non-small cell lung cancer

Lobectomy with lymph node dissection long has been the standard surgical treatment for non-small cell lung cancer (NSCLC). A landmark study by the Lung Cancer Study Group in 1995 made comparison between lobectomy and sublobar resection (segmentectomy or wedge resection) of stage IA NSCLC, and demonstrated that sublobar resection was associated with inferior overall survival (OS) and three times the local recurrence rate compared to lobectomy (1).